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DeCS
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Descriptor English:
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Cytochrome P-450 Enzyme System
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Descriptor Spanish:
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Sistema Enzimático del Citocromo P-450
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Descriptor Portuguese:
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Sistema Enzimático do Citocromo P-450
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Synonyms English:
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Cytochrome P-450
Cytochrome P-450-Dependent Monooxygenase
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Tree Number:
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D08.244.453
D08.811.682.690.708.170
D12.776.422.220.453
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Definition English:
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A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism. |
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Indexing Annotation English:
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GEN or unspecified; prefer specific cytochrome P-450's; /biosyn /physiol permitted
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History Note English:
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73; CYTOCHROME P-450 OXYGENASE was NM 1977-96
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Allowable Qualifiers English:
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Record Number:
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3595
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Unique Identifier:
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D003577
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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